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Guanidine containing co-polymers grafted onto silica nanoparticles to form core-shell

structure were prepared by sol-gel method in the presence of γ-Fe₂O₃ nanoparticles.

The morphological features for uncoated and coated silica particles have been

characterized with scanning electron microscopy. The results show that the polymer

coated silicas exhibit spherical morphology with rough polymeric surface covered by

γ-Fe₂O₃ nanoparticles. The grafting amount of guanidine containing co-polymers

evaluated by thermogravimetric analysis was in the range from 17 to 30%. Then, the

drug loading properties and cumulative release of silica hybrids modified with

guanidine containing co-polymers were evaluated using molsidomine as a model

drug. It was shown that after polymer grafting the loading content of molsidomine

could reach up to 3.42 ± 0.21 and 2.34 ± 0.14 mg/g respectively. The maximum

drug release of molsidomine is achieved at pH 1.6 (approximately 71–75% release at

37 °C), whereas at pH 7.4 drug release is lower (50.4–59.6% release at 37 °C). These

results have an important implication that our magneto-controlled silica hybrids

modified with guanidine containing co-polymers are promising as drug carriers with

controlled behaviour under influence of magnetic field.

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